Product Description: RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA). RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer[1].
Applications: Cancer-Kinase/protease
Formula: C109H181N25O35
References: [1]Autenrieth K, et al. Defining A‐kinase anchoring protein (AKAP) specificity for the protein kinase A subunit RI (PKA‐RI)[J]. Chembiochem, 2016, 17(8): 693-697.
Molecular Weight: 2401.75
Research Area: Cancer; Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: PKA
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