Product Description: Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2].
Applications: COVID-19-immunoregulation
Formula: C25H27ClN2O4
References: [1]Manuel Hitzenberger, et al. The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study. Front Chem/[2]Benjamin Z Stanton, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6./[3]Ronald S Petralia, et al. Sonic hedgehog promotes autophagy in hippocampal neurons. Biol Open. 2013 Apr 8;2(5):499-504./[4]Ke Cai, et al. Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myeloma. Leuk Lymphoma. 2019 Mar;60(3):772-781.
CAS Number: 1132653-79-2
Molecular Weight: 454.95
Compound Purity: 99.42
Research Area: Inflammation/Immunology
Solubility: DMSO : 20 mg/mL (ultrasonic;warming)
Target: Hedgehog
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