RTx-152

Product Description: RTx-152 traps Polθ on DNA and is an allosteric Polθ-pol inhibitor (IC50: 6.2 nM). RTx-152 selectively kills HR-deficient cancer cells, and suppresses PARP inhibitor resistance in multiple genetic backgrounds, including homologous recombination (HR)-proficient cells. RTx-152 selectively kills BRCA2-null cells[1].

Applications: Cancer-programmed cell death

Formula: C20H16F7N3O3

References: [1]Fried W, et al. Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nat Commun. 2024 Apr 5;15(1):2862.

Molecular Weight: 479.35

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: DNA/RNA Synthesis

• SKU: MEXHY-161431-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161431-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK