Product Description: RTx-161 is an allosteric Polθ polymerase inhibitor with an IC50 value of 4.1 nM. RTx-161 selectively kills HR-deficient cancer cells and suppresses PARP inhibitor (PARPi) resistance in multiple genetic backgrounds, including HR-proficient cells. Additionally, RTx-161 can induce apoptosis[1].
Formula: C21H18F7N3O4
References: [1]Fried W, et al. Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors[J]. Nature communications, 2024, 15(1): 2862.
Molecular Weight: 509.37
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Apoptosis;DNA/RNA Synthesis