Product Description: SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems[1].
Formula: C13H10F4N2O3
References: [1]Lee WL, et al. Molecular Design of SERTlight: A Fluorescent Serotonin Probe for Neuronal Labeling in the Brain. J Am Chem Soc. 2024;146(14):9564-9574.
Molecular Weight: 318.22
Research Area: Neurological Disease
Solubility: 10 mM in DMSO
Target: Fluorescent Dye
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