SHMT-IN-2, CAS 2102681-49-0

Product Description: SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas[1].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C22H24F3N5O

References: [1]regory S Ducker, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.

CAS Number: 2102681-49-0

Molecular Weight: 431.45

Compound Purity: 99.50

Research Area: Cancer; Endocrinology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: SHMT

• SKU: MEXHY-129226-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-129226-10.1
• Green Labware: No
• Package Unit: 10mM/1mL
• Quantity Unit: STK