SIK-IN-2, CAS 3033846-20-4

Product Description: SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 2 nM in human macrophages[1].

Applications: COVID-19-immunoregulation

Formula: C22H22N6OS

References: [1]Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1.

CAS Number: 3033846-20-4

Molecular Weight: 418.51

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: AMPK

• SKU: MEXHY-161441-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161441-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK