Product Description: SIK-IN-3 (Compound 6B) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.3 and 0.8 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.6 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 3 nM in human macrophages[1].
Applications: COVID-19-immunoregulation
Formula: C24H25N5OS
References: [1]Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1.
Molecular Weight: 431.55
Research Area: Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: AMPK