Simvastatin acid (calcium hydrate), CAS 530112-57-3

Product Description: Simvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid calcium hydrate can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].

Applications: COVID-19-immunoregulation

Formula: C25H40O6.1/2Ca.xH2O

References: [1]Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45(Pt 1):158-165./[2]Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272.

CAS Number: 530112-57-3

Molecular Weight: N/A

Research Area: Inflammation/Immunology; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: HMG-CoA Reductase (HMGCR);Reactive Oxygen Species

• SKU: MEXHY-119695B-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-119695B-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK