SMD-3040, CAS 3033109-92-8

Product Description: SMD-3040 is a potent and selective of SMARCA2 PROTAC degrader (DC50: 12 nM). SMD-3040 contains SMARCA2/4 ligand, linker and VHL ligand. SMD-3040 demonstrates excellent degradation selectivity for SMARCA2 protein over SMARCA4 protein.SMD-3040 achieves strong tumor growth inhibition in xenograft models[1].

Applications: Cancer-programmed cell death

Formula: C52H66N10O5S

References: [1]Yang L, et.al. Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity. J Med Chem. 2023 Jul 31.

CAS Number: 3033109-92-8

Molecular Weight: 943.21

Research Area: Cancer

Solubility: DMSO : ≥ 100 mg/mL

Target: Epigenetic Reader Domain;PROTACs

• SKU: MEXHY-156568-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-156568-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK