Smurf1-IN-1, CAS 1824708-03-3

Product Description: Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension[1].

Applications: Neuroscience-Neuromodulation

Formula: C24H29ClN6O2

References: [1]Shaw DE, et.al. Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension. J Med Chem. 2023 Jun 22;66(12):8130-8139.

CAS Number: 1824708-03-3

Molecular Weight: 468.98

Compound Purity: 99.47

Research Area: Cardiovascular Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: E1/E2/E3 Enzyme

• SKU: MEXHY-149316-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-149316-10.1
• Green Labware: No
• Package Unit: 10mM/1mL
• Quantity Unit: STK