Sorafenib, CAS 284461-73-0

Description: Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity and can induce autophagy and apoptosis as well as agonistic iron death.

CAS Number: 284461-73-0

Formula: C21H16ClF3N4O3

Molecular Weight: 464,82

References: Wei JC, et al. Sorafenib inhibits proliferation and invasion of human hepatocellular carcinoma cells via up-regulation of p53 and suppressing FoxMActa Pharmacol Sin. 2015 Feb;36(2):241-51.

• SKU: TGMT0093L-1mL
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T0093L-1mL
• Package Unit: 1 mL
• Quantity Unit: STK