SR-0813, CAS 2597186-19-9

Product Description: SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC50 and EC50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity (Kd=3.5 μM) than ENL YEATS (Kd=30 nM). SR-0813 can be used for the research of acute leukemia[1].

Applications: Cancer-programmed cell death

Formula: C25H32N6O3S

References: [1]Garnar-Wortzel L, et al. Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. ACS Cent Sci. 2021 May 26;7(5):815-830.

CAS Number: 2597186-19-9

Molecular Weight: 496.62

Compound Purity: 99.93

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Epigenetic Reader Domain

• SKU: MEXHY-145409-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-145409-10.1
• Green Labware: No
• Package Unit: 10mM/1mL
• Quantity Unit: STK