Product Description: Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1][2].
Applications: COVID-19-immunoregulation
Formula: C22H36NNaO7S
Citations: J Exp Med. 2023 Mar 6;220(3):e20221316./J Transl Med. 2023 Feb 6;21(1):89./Research Square Preprint. 2023 Oct 11./Research Square Print. December 29th, 2022./BMC Cancer. 2023 Apr 21;23(1):367./Cancer Lett. 2023 Nov 25, 216511./Cell Immunol. 11 January 2022, 104475./CNS Neurosci Ther. 2023 May 8./Food Res Int. 2023 Nov, 173, 113328./Food Sci Nutr. 2023 Nov 22./Front Pharmacol. 2020 Dec 16;11:593832./Int J Biol Macromol. 2023 Oct 12:127324./Int J Mol Sci. 2023 Aug 31, 24(17), 13516./SSRN. 2023 Aug 30./Toxicol Sci. 2022 Dec 19;kfac133./Toxins. 2021, 13(11), 802.
References: [1]Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237./[2]Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51.
CAS Number: 1212012-37-7
Molecular Weight: 481.58
Compound Purity: 98.0
Research Area: Inflammation/Immunology
Solubility: DMSO : 62.5 mg/mL (ultrasonic)
Target: Mitophagy
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