SWTX-143, CAS 2766575-48-6

Product Description: SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity[1].

Formula: C19H18F3N3O

References: [1]Hanne Hillen, et al. A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models. Mol Cancer Ther. 2023 Sep 23.

CAS Number: 2766575-48-6

Molecular Weight: 361.36

Compound Purity: 99.81

Research Area: cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: YAP

• SKU: MEXHY-155338-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-155338-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK