TAK-243, CAS 1450833-55-2

Description: TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis.

CAS Number: 1450833-55-2

Formula: C19H20F3N5O5S2

Molecular Weight: 519,52

References: Zhuang J, et al. Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma. Blood. 2019 Apr 4;133(14):1572-1584.

• SKU: TGMT16974-10mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T16974-10mg
• Package Unit: 10 mg
• Quantity Unit: STK