TGFβRII-IN-3

Product Description: TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) (IC50 = 4.1 μM). TGFβRII-IN-3 inhibits TGFβ signaling by promoting the proteolytic degradation of TGFβ RII. TGFβRII-IN-3 can block endothelial-to-mesenchymal transition and cell migration. TGFβRII-IN-3 can be used in cancer research[1].

Applications: Cancer-Kinase/protease

Formula: C26H25F3N2O2

References: [1]Längle D, et al.Expanding the Chemical Space of Transforming Growth Factor-β (TGFβ) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives. ACS Pharmacol Transl Sci. 2024 Mar 21;7(4):1069-1085.

Molecular Weight: 454.48

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: TGF-beta/Smad;TGF-β Receptor

• SKU: MEXHY-161398-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161398-0
• Package Unit: Get quote
• Quantity Unit: STK