Thalidomide-5-propargyl, CAS 2226303-74-6

Thalidomide-5-propargyl, CAS 2226303-74-6
SKU
MEXHY-W457950-25
Packaging Unit
25 mg
Manufacturer
MedChemExpress

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Product Description: Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1].

Formula: C16H12N2O5

References: [1]Crew, et al. Preparation of tau-protein targeting bifunctional compounds (PROTACS) as E3 ubiquitin ligase binding useful in treatment and prevention of diseases. United States, US20180125821 A1. 2018-05-10.

CAS Number: 2226303-74-6

Molecular Weight: 312.28

Compound Purity: 95.87

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Autophagy;E3 Ligase Ligand-Linker Conjugates
More Information
SKU MEXHY-W457950-25
Manufacturer MedChemExpress
Manufacturer SKU HY-W457950-25
Green Labware No
Package Unit 25 mg
Quantity Unit STK
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