Thalidomide-NHCH2-Ph-pyrimidine-NH2

Product Description: Thalidomide-NHCH2-Ph-pyrimidine-NH2 is a conjugate of E3 ligase ligand and linker, which is consisted of a Thalidomide (HY-14658) and a Linker Boc-NHCH2-Ph-pyrimidine-NH2 (HY-161499). Thalidomide-NHCH2-Ph-pyrimidine-NH2 is utilized for synthesis of PROTAC molecule XYD198 (HY-161498)[1].

Applications: Cancer-programmed cell death

Formula: C24H20N6O4

References: [1]Hu J, et al., Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor Activity. J Med Chem. 2024 May 9;67(9):6952-6986. 

Molecular Weight: 456.45

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: E3 Ligase Ligand-Linker Conjugates

• SKU: MEXHY-161500-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161500-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK