Thalidomide (Standard), CAS 50-35-1

Thalidomide (Standard), CAS 50-35-1
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MEXHY-14658R-0
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MedChemExpress

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Product Description: Thalidomide (Standard) is the analytical standard of Thalidomide. This product is intended for research and analytical applications. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.

Formula: N/A

References: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53./[2]Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203./[3]Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453.

CAS Number: 50-35-1

Molecular Weight: N/A

Research Area: Cancer; Inflammation/Immunology

Target: Apoptosis;Autophagy;E3 Ligase Ligand-Linker Conjugates
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SKU MEXHY-14658R-0
Manufacturer MedChemExpress
Manufacturer SKU HY-14658R-0
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