Tiratricol (Standard), CAS 51-24-1

Product Description: Tiratricol (Standard) is the analytical standard of Tiratricol. This product is intended for research and analytical applications. Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC50s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication.[2].

Formula: N/A

References: [1]Ren H, et al. Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5. Antiviral Res. 2023 Nov;219:105737./[2]Cascales L, et al. Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell. Chem Biol Drug Des. 2008 Oct;72(4):320-8.

CAS Number: 51-24-1

Molecular Weight: N/A

Research Area: Endocrinology

Target: Flavivirus;Thyroid Hormone Receptor;TNF Receptor

• SKU: MEXHY-B1201R-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-B1201R-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK