TNIK-IN-9

Product Description: TNIK-IN-9 (Compound 54) is a selective and potent NIK inhibitor, with an IC50 of 1.27 nM. TNIK-IN-9 can inhibit pro-inflammatory cytokines and nitric oxide production. TNIK-IN-9 exhibits significant anti-inflammatory effects, improved mortality, and hepatoprotective effects in sepsis models[1].

Formula: C24H21N7O3S

References: [1]Zhang N, et al. Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment. J Med Chem. 2024 Apr 11;67(7):5617-5641.

Molecular Weight: 487.53

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: NF-κB

• SKU: MEXHY-163478-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-163478-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK