Tominersen (sodium)

Product Description: Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD)[1][2].

Applications: Neuroscience-Neurodegeneration

Formula: C230H299N74Na20O122P19S13

References: [1]Kordasiewicz HB, et al. Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron. 2012 Jun 21;74(6):1031-44./[2]Tabrizi SJ, et, al. Targeting Huntingtin Expression in Patients with Huntington's Disease. N Engl J Med. 2019 Jun 13;380(24):2307-2316.

Molecular Weight: 7517.39

Compound Purity: 97.34

Research Area: Neurological Disease

Solubility: 10 mM in H2O

Target: Huntingtin

• SKU: MEXHY-132579A-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-132579A-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK