TOPOI/PARP-1-IN-1, CAS 2948352-16-5

Product Description: TOPOI/PARP-1-IN-1 (Compound B6) is an orally active, low cytotoxic TOPOI/PARP dual inhibitor with an IC50 value of 0.09 μM for PARP1. TOPOI/PARP-1-IN-1 can effectively inhibit the proliferation and migration of cancer cells. TOPOI/PARP-1-IN-1 also causes cell cycle arrest in the G0/G1 phase and induces apoptosis. The tumor growth inhibition rate (TGI) of TOPOI/PARP-1-IN-1 in mice was 75.4%[1].

Applications: Cancer-programmed cell death

Formula: C36H38Br2N4O2

References: [1]Qiu G, et al. Design, synthesis and biological evaluation of matrine contains benzimidazole derivatives as dual TOPOI and PARP inhibitors for cancer therapy. Eur J Med Chem. 2024 Mar 27;270:116348.

CAS Number: 2948352-16-5

Molecular Weight: 718.52

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;PARP;Topoisomerase

• SKU: MEXHY-158138-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158138-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK