Product Description: Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO[1].
Formula: C15H11Cl2N5
References: [1]Al-Karmalawy AA, et al. Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Nov 5;259:115661.
CAS Number: 305343-00-4
Molecular Weight: 332.19
Compound Purity: 99.68
Research Area: cancer
Solubility: DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Apoptosis;Topoisomerase