TPBM, CAS 6466-43-9

Product Description: TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for 17β-estradiol (E2)-ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC50=5 μM). TPBM is not toxic to cells and does not affect estrogen-independent cell growth[1].

Applications: Cancer-programmed cell death

Formula: C15H16N4O2S

References: [1]Mao C, et al. A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. J Biol Chem. 2008;283(19):12819-12830.

CAS Number: 6466-43-9

Molecular Weight: 316.38

Compound Purity: 98.51

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Estrogen Receptor/ERR

• SKU: MEXHY-131404-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-131404-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK