Tubulin inhibitor 42, CAS 2135713-96-9

Product Description: Tubulin inhibitor 42 dose-dependently inhibited the activity of β-microtubulin (IC50 = 3.5 µM).Tubulin inhibitor 42 interferes with microtubule dynamic homeostasis, resulting in the arrest of the cancer cell cycle in the G2/M phase and inducing apoptosis. Tubulin inhibitor 42 significantly inhibits the angiogenic process in vitro and in vivo, preventing vascularization and tumor growth[1].

Formula: C20H23NO7

References: [1]Zhou P, et al.Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents. Eur J Med Chem. 2018 Jan 20;144:817-842. 

CAS Number: 2135713-96-9

Molecular Weight: 389.40

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Microtubule/Tubulin

• SKU: MEXHY-160853-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-160853-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK