Product Description: TYM-3-98 is a selective inhibitor for PI3Kδ, with an IC50 of 7.1 nM. TYM-3-98 inhibits proliferationso of B-lymphoma cells. TYM-3-98 inhibits PI3K/AKT/mTOR signaling pathway through induction of apoptosis. TYM-3-98 exhibits good pahrmacokinetic characters and antitumor efficacy in mouse/rat model, without significant toxicity[1].
Formula: C28H23ClFN7O3S
References: [1]Lou SY, et al., TYM-3-98, a novel selective inhibitor of PI3Kδ, demonstrates promising preclinical antitumor activity in B-cell lymphomas. Life Sci. 2024 Jun 15;347:122662.
Molecular Weight: 592.04
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Apoptosis;PI3K