Product Description: VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission[1][2].
Formula: C16H14N4OS2
References: [1]Delpire E, et al. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2.
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8./[2]Wang Y, et al. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses. Neuroscience. 2015;298:397-409./[3]Balapattabi K, et al. Effects of salt-loading on supraoptic vasopressin neurones assessed by ClopHensorN chloride imaging. J Neuroendocrinol. 2019;31(8):e12752.
CAS Number: 893990-34-6
Molecular Weight: 342.44
Compound Purity: 99.97
Research Area: Others
Solubility: DMSO : ≥ 50 mg/mL
Target: Potassium Channel
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