XRD-0394, CAS 2595308-10-2

Product Description: XRD-0394 is a potent and specific dual inhibitor of ATM and DNA-PKcs with oral activity. XRD-0394 significantly enhances tumor cell killing in vitro and in vivo under therapeutic ionizing radiation conditions. In addition, XRD-0394 can potentiate the effects of PARP and topoisomerase I inhibitors in vitro[1].

Formula: C26H30FN5O4S

References: [1]Gilmer T M, et al. A novel dual ATM/DNA-PK inhibitor, XRD-0394, potently radiosensitizes and potentiates PARP and topoisomerase I inhibitors[J]. Molecular Cancer Therapeutics, 2024.

CAS Number: 2595308-10-2

Molecular Weight: 527.61

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ATM/ATR;DNA-PK

• SKU: MEXHY-162472-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-162472-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK