Zamicastat, CAS 1080028-80-3

Product Description: Zamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8 μM and 17.0 μM, respectively[1]. Zamicastat reduces high blood pressure[2].

Applications: Cancer-programmed cell death

Formula: C21H21F2N3OS

References: [1]Bicker J, et al. In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein. Eur J Pharm Sci. 2018 May 30;117:35-40./[2]Igreja B, et al. Effects of Zamicastat treatment in a genetic model of salt-sensitive hypertension and heart failure. Eur J Pharmacol. 2019 Jan 5;842:125-132.

CAS Number: 1080028-80-3

Molecular Weight: 401.47

Compound Purity: 99.95

Research Area: Cancer; Cardiovascular Disease

Solubility: DMSO : 150 mg/mL (ultrasonic)

Target: BCRP;Dopamine β-hydroxylase;P-glycoprotein

• SKU: MEXHY-106004-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-106004-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK