5-HT1AR agonist 1

Product Description: 5-HT1AR agonist 1 (Compound A3) emerges as a relatively balanced multi-target activity profile, including 5-HT1AR agonist with an EC50 value of 34 nM, SERT reuptake ihibitor (IC50 =12 nM), NET reuptake inhibitor (IC50 =78 nM) and DAT reuptake inhibitor (IC50 =135 nM). 5-HT1AR agonist 1 performs significant antidepressant effects and exhibits excellent bioavailability and low clearance in mice, which is promising for research in the field of antidepressant drugs[1].

Formula: C24H26N4O3

References: [1]Zheng J, et al. Synthesis and biological evaluation of multimodal monoaminergic arylpiperazine derivatives with potential antidepressant profile[J]. Eur J Med Chem. 2024 Jun 3;275:116564.

Molecular Weight: 418.49

Research Area: Neurological Disease

Target: 5-HT Receptor

• SKU: MEXHY-162585-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-162585-0
• Package Unit: Get quote
• Quantity Unit: STK