A11, CAS 2412926-29-3

Product Description: A11 (ANXA1-derived 11 amino acid–long peptide) is an ANXA1-EphA2 interaction blocker peptide. A11 decreases ANXA1 bound to EphA2 and increased Cbl (an E3 ubiquitin ligase of EphA2) bound to EphA2. A11 efficiently decreases EphA2 level, and substantially increases EphA2 ubiquitination. A11 increases EphA2 internalization and colocalization of EphA2 and Cbl in the NPC cells. A11 inhibits nasopharyngeal carcinoma (NPC) cell proliferation, migration and invasion. A11 inhibits angiogenesis[1].

Formula: C53H88N14O19

References: [1]Feng J, et al. ANXA1 Binds and Stabilizes EphA2 to Promote Nasopharyngeal Carcinoma Growth and Metastasis. Cancer Res. 2020 Oct 15;80(20):4386-4398.

CAS Number: 2412926-29-3

Molecular Weight: 1225.35

Research Area: Cancer

Target: Ephrin Receptor

• SKU: MEXHY-P10412-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P10412-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK