Product Description: Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C17H19ClN4O
References: [1]Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome By Spiller, Robin C. From Current Opinion in Pharmacology (2011), 11(1), 68-74./[2]Lucak SL.
Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome.
Therap Adv Gastroenterol. 2010 May;3(3):165-72./[3]Lewis JH.
Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective.
Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):13-29./[4]Turgeon DK, Tayeh N, Fontana RJ.
Acute hepatitis associated with alosetron (Lotronex).
J Clin Gastroenterol. 2005 Aug;39(7):641-2./[5]Miller DP, Alfredson T, Cook SF, Sands BE, Walker AM.
Incidence of colonic ischemia, hospitalized complications of constipation, and bowel surgery in relation to use of alosetron hydrochloride.
Am J Gastroenterol. 2003 May;98(5):1117-22./[6]Balfour JA, Goa KL, Perry CM. Alosetron. Drugs. 2000;59(3):511-520./[7]Motavallian A, et al. Anti-inflammatory effects of alosetron mediated through 5-HT3 receptors on experimental colitis. Res Pharm Sci. 2019;14(3):228-236.
CAS Number: 122852-69-1
Molecular Weight: 330.81
Compound Purity: 99.76
Research Area: Neurological Disease
Solubility: H2O : 33.33 mg/mL (ultrasonic)
Target: 5-HT Receptor
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