Antitumor agent-177

Product Description: Antitumor agent-177 (compound 57), a non-steroidal NSC12 derivative, shows potent FGF2 binding affinity with a Kd of 24 μM by SPR. Antitumor agent-177 significantly inhibits the formation of HSPG/FGF2/FGFR1 ternary complexes. Antitumor agent-177 inhibits FGFR activation and exerts a potent anti-tumor activity on multiple myeloma (MM) cell lines in vitro and in vivo[1].

Applications: Cancer-Kinase/protease

Formula: C28H21F7O4

References: [1]Sara Taranto, et al. Discovery of novel FGF trap small molecules endowed with anti-myeloma activity. Pharmacol Res. 2024 Jul 3:206:107291.

Molecular Weight: 554.45

Research Area: Cancer

Target: FGFR

• SKU: MEXHY-161841-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161841-0
• Package Unit: Get quote
• Quantity Unit: STK