AZ683, CAS 953798-95-3

Product Description: AZ683 is a potent and selective 3-amido-4-anilinoquinoline CSF1R inhibitor. AZ683 has high affinity for CSF1R (Ki=8 nM; IC50=6 nM). AZ683 has good oral bioavailability. [11C]AZ683 can be used as a positron emission tomography (PET) radiotracer for colony stimulating factor 1 receptor (CSF1R)[1][2].

Formula: C23H25F2N5O2

References: [1]Tanzey SS, et al. Synthesis and Initial In Vivo Evaluation of [11C]AZ683-A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R). Pharmaceuticals (Basel). 2018 Dec 13;11(4):136. /[2]Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6.

CAS Number: 953798-95-3

Molecular Weight: 441.47

Research Area: Cardiovascular Disease

Target: c-Fms

• SKU: MEXHY-159108-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-159108-0
• Package Unit: Get quote
• Quantity Unit: STK