BMS-911543, CAS 1271022-90-2

Product Description: BMS-911543 is a selective JAK2 inhibitor, with IC50s of 1.1 nM, less selective at JAK1, JAK3 and TYK2 (IC50, 75, 360, 66 nM, respectively).

Applications: Cancer-Kinase/protease

Formula: C23H28N8O

References: [1]Wan H, et al. Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms. ACS Med Chem Lett. 2015 Jul 12;6(8):850-5./[2]Mace TA, et al. Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer. Oncotarget. 2015 Dec 29;6(42):44509-22.

CAS Number: 1271022-90-2

Molecular Weight: 432.52

Compound Purity: 98.53

Research Area: Cancer

Solubility: DMSO : 25 mg/mL (ultrasonic)

Target: JAK

• SKU: MEXHY-15270-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-15270-25
• Package Unit: 25 mg
• Quantity Unit: STK