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Applications: Useful for cell-binding studies.
Background: BTN2A1 (butyrophilin subfamily 2 member A1), or butyrophilin 2A1, is a type I transmembrane protein that belongs to the Ig-superfamily and is structurally similar to the B7 family. It is involved in T cell function, functioning as an immune checkpoint. BTN2A1 is a ligand for Vγ9+ TCR γ chain (T Cell Receptors), binding to BTN3A1 and initiating a response from γδ T cells to phosphoantigens. Vγ9Vδ2 T cells can fight cancer, being cytotoxic when activated by the presence of accumulated IPP (isopentenyl diphosphate) in cancer cells. BTN2A1 is expressed in cancer cells and the use of specific activating monoclonal antibodies can potentiate the response of Vγ9Vδ2 T cell-based therapies.
Description: Recombinant human BTN2A1 (butyrophilin subfamily 2 member A1), encompassing amino acids 29-248 corresponding to the extracellular domain. This construct has a Fc domain on the C-terminus, followed by an Avi-Tag™. This protein was affinity purified.
Endotoxin Level: <0.65 EU/mg
Format: Aqueous buffer solution
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_007049.5
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Fc-Avi-Tag
Uniprot: Q7KYR7
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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