Product Description: Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
Applications: COVID-19-immunoregulation
Formula: C9H10Cl3N3
Citations: Cell Rep. 2019 Dec 3;29(10):2929-2935.e4/Elife. 2024 May 29./Neurosci Bull. 2022 Apr;38(4):386-402./medRxiv. 2024 May 31.
References: [1]Bugajski J, et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19(1):9-15./[2]Zhang YM, et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30(9):1746-52./[3]Jentsch JD, et al. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6./[4]Nassar N, et al. Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1/2-dependent hypotensive action of clonidine in conscious normotensive rats. J Pharmacol Exp Ther. 2009 Jan;328(1):83-9.
CAS Number: 4205-91-8
Molecular Weight: 266.55
Compound Purity: 99.96
Research Area: Cardiovascular Disease; Endocrinology; Cancer
Solubility: DMSO : 7.6 mg/mL (ultrasonic;warming)/H2O : 33.33 mg/mL (ultrasonic)
Target: Adrenergic Receptor
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