Product Description: Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and 5-HT1B receptor (Ki: 2.1 and 3 nM respectively)[1][2][3].
Formula: C16H21N3O2
References: [1]Hoey A, et al. Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol. Br J Pharmacol. 1996 Feb;117(4):712-6. /[2]Schlicker E, et al. Cyanopindolol is a highly potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol. 1985 Dec;331(4):398-401. /[3]Langlois M, et al. Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors. Eur J Pharmacol. 1993 Jan 4;244(1):77-87.
CAS Number: 69906-85-0
Molecular Weight: 287.36
Research Area: Neurological Disease
Target: 5-HT Receptor;Adrenergic Receptor
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