Cyclic AC253

Product Description: Cyclic AC253 is an antagonist for amylin receptor, with IC50 of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB)[1].

Applications: Neuroscience-Neurodegeneration

Formula: C126H202N42O40S2

References: [1]Soudy R, et al., Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease. Alzheimers Dement (N Y). 2016 Dec 10;3(1):44-56.

Molecular Weight: 3009.34

Compound Purity: 99.87

Research Area: Neurological Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Amylin Receptor

• SKU: MEXHY-P10235-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P10235-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK