Cyclo(CKLIIF) (TFA)

Product Description: Cyclo CKLIIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 2.6 and 2.2 μM, respectively[1].

Applications: Cancer-programmed cell death

Formula: C36H59N7O6S.xC2HF3O2

References: [1]Ball AT, et al., Identification and Development of Cyclic Peptide Inhibitors of Hypoxia Inducible Factors 1 and 2 That Disrupt Hypoxia-Response Signaling in Cancer Cells. J Am Chem Soc. 2024 Mar 19.

Molecular Weight: 717.96 (free base)

Research Area: Cancer

Target: HIF/HIF Prolyl-Hydroxylase

• SKU: MEXHY-P10221A-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P10221A-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK