Product Description: DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC50 value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome[1][2].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C19H28Cl2N6O2
References: [1]Lee D Y, et al. Pharmacokinetics of DA-6886, a new 5-HT4 receptor agonist, in rats[J]. Pharmaceutics, 2022, 14(4): 702./[2]Lee M J, et al. Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice[J]. European Journal of Pharmacology, 2014, 735: 115-122.
CAS Number: 1645260-76-9
Molecular Weight: 443.37
Research Area: Endocrinology; Neurological Disease
Target: 5-HT Receptor
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