DHFR-IN-4, CAS 2820126-49-4

Product Description: DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with an IC50 value of 123 nM. DHFR-IN-4 also has inhibitory activity against EGFR and HER2 with IC50s of 246 nM and 357 nM, respectively. DHFR-IN-4 has remarkable broad spectrum cytotoxic potency against cancer cells[1].

Applications: Cancer-Kinase/protease

Formula: C18H21N5O2S

References: [1]Sabry MA, et al. New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity. Eur J Med Chem. 2022 Aug 10;241:114661.

CAS Number: 2820126-49-4

Molecular Weight: 371.46

Compound Purity: 99.19

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: Dihydrofolate reductase (DHFR) ;EGFR

• SKU: MEXHY-151159-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-151159-1
• Package Unit: 1 mg
• Quantity Unit: STK