EGFR-IN-117, CAS 3035639-05-2

Product Description: EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutation, targets the tumor environment, and induces apoptosis of cancer cells. EGFR-IN-117 inhibits proliferations of H1975, PC-9, and EGFR mutant cells BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 of 13 nM, 19 nM, 1.2 nM and 1.3 nM, respectively. EGFR-IN-117 exhibits antitumor efficacy in mouse models[1].

Formula: C25H30BrN7O2S

References: [1]Yao H, et al., Discovery of new cyclopropane sulfonamide derivatives as EGFR inhibitors to overcome C797S-mediated resistance and EGFR double mutation. Eur J Med Chem. 2024 Jun 16;275:116590.

CAS Number: 3035639-05-2

Molecular Weight: 572.52

Research Area: Cancer

Target: Apoptosis;EGFR

• SKU: MEXHY-161785-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161785-0
• Package Unit: Get quote
• Quantity Unit: STK