EPHA2/A4/GAK-IN-1

Product Description: EPHA2/A4/GAK-IN-1 (compound 55) is a potent inhibitor of EPHA2/EPHA4 and GAK with KD values of 180.5 nM for EPHA2 and 19.2 nM for GAK, respectively. EPHA2/GAK-IN-1 shows an extrapolated half-life time of 4.6 h in a microsomal stability assay. EPHA2/GAK-IN-1 shows antiviral activity and prevents dengue virus infection of Huh7 liver cells[1].

Formula: C20H20BrN5O3S

References: [1]Joshua Gerninghaus, et al. Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. J Med Chem. 2024 Jul 19.

Molecular Weight: 490.37

Research Area: Infection

Target: Cyclin G-associated Kinase (GAK);Dengue virus;Ephrin Receptor

• SKU: MEXHY-159174-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-159174-0
• Package Unit: Get quote
• Quantity Unit: STK