FGFR-IN-14

Product Description: FGFR-IN-14 (compound 10h) is a pan-FGFR inhibitor. FGFR-IN-14 inhibits FGFR1, FGFR2, FGFR3 and FGFR2 V564F gatekeeper mutant with IC50s of 46, 41, 99, and 62 nM, respectively. FGFR-IN-14 strongly suppresses NCI-H520 lung cancer cells, SNU-16 and KATO III gastric cancer cells proliferation with IC50s of 19, 59, and 73 nM, respectively[1].

Formula: C24H19F2N7O2

References: [1]Deng W, et al. Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors. Eur J Med Chem. 2024 Jun 9;275:116558.

Molecular Weight: 475.45

Research Area: Cancer

Target: FGFR

• SKU: MEXHY-162577-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-162577-0
• Package Unit: Get quote
• Quantity Unit: STK