FLT3D835Y/F691L-IN-1

Product Description: FLT3D835Y/F691L-IN-1 (compd 8v) is an orally active inhibitor of FLT3 3-tyrosine kinase domain D835Y/F691L secondary mutations with IC50s of 1.5 and 9.7 nM. FLT3D835Y/F691L-IN-1 can be used for acute myeloid leukemia research[1].

Applications: Cancer-Kinase/protease

Formula: C26H37N7O4

References: [1]Zheng X, et al. Structure-Based Optimization of Pyrazinamide-Containing Macrocyclic Derivatives as Fms-like Tyrosine Kinase 3 (FLT3) Inhibitors to Overcome Clinical Mutations. ACS Pharmacol Transl Sci. 2024 Apr 11;7(5):1485-1506.

Molecular Weight: 511.62

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: FLT3

• SKU: MEXHY-158265-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158265-0
• Package Unit: Get quote
• Quantity Unit: STK