GRK2 Inhibitor 2, CAS 2592436-21-8

Product Description: GRK2 Inhibitor 2 (Compound 8h) is a GRK2 inhibitor (IC50: 19 nM). GRK2 Inhibitor 2 also inhibits Aurora-A (IC50: 137 nM). GRK2 Inhibitor 2 promotes β-AR-mediated cAMP accumulation in GRK2-overexpressed HEK293 cells. GRK2 Inhibitor 2 can be used for research of congestive heart failure (HF)[1].

Applications: Neuroscience-Neuromodulation

Formula: C19H16N4O2

References: [1]Xu G, et al. Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127602.

CAS Number: 2592436-21-8

Molecular Weight: 332.36

Compound Purity: 98.88

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: G Protein-coupled Receptor Kinase (GRK)

• SKU: MEXHY-156863-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-156863-5
• Package Unit: 5 mg
• Quantity Unit: STK