GTS-21, CAS 148372-04-7

Product Description: GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist. GTS-21 can be used in age-associated memory impairment (AAMI) and Alzheimer's disease research[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C19H20N2O2

References: [1]Briggs CA, et al. Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol Biochem Behav. 1997;57(1-2):231-241./[2]Zhang R, et al. N-terminal domains in mouse and human 5-hydroxytryptamine3A receptors confer partial agonist and antagonist properties to benzylidene analogs of anabaseine. J Pharmacol Exp Ther. 2006;317(3):1276-1284./[3]Mei Z, et al. α7 nAchR agonist GTS 21 reduces radiation induced lung injury. Oncol Rep. 2018;40(4):2287-2297.

CAS Number: 148372-04-7

Molecular Weight: 308.37

Research Area: Inflammation/Immunology

Target: 5-HT Receptor;nAChR

• SKU: MEXHY-14564-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-14564-0
• Package Unit: Get quote
• Quantity Unit: STK